Moxie can refer to courage and determination (aka nerve), energy and pep (aka verve), or know-how (as, say, reflected in one’s oeuvre).
They showed a lot of moxie in questioning their company’s policy.
She clearly doesn’t need coffee to start her day full of moxie.
The lead actor’s musical moxie inspired the addition of a serenade at the close of the play’s first act.